| WEEK 16 GAMES | ||||
| Favorite | Line | Underdog | ||
| Thursday | ||||
| At Pittsburgh | -14 | Carolina | ||
| Saturday | ||||
| Dallas | -7 | At Arizona | ||
| Sunday | ||||
| At Miami | -3.5 | Detroit | ||
| At Philadelphia | -14.5 | Minnesota | ||
| At Jacksonville | -7 | Washington | ||
| At St. Louis | -2.5 | San Francisco | ||
| At Tampa Bay | -6 | Seattle | ||
| New England | -8 | At Buffalo | ||
| At Chicago | -1 | NY Jets | ||
| Baltimore | -3.5 | At Cleveland | ||
| At Kansas City | -5 | Tennessee | ||
| Indianapolis | -3 | At Oakland | ||
| Houston | -2.5 | At Denver | ||
| At Green Bay | -3 | NY Giants | ||
| San Diego | -7.5 | At Cincinnati | ||
| Monday | ||||
| At Atlanta | -2.5 | New Orleans | ||